انجمن آترواسکلروز ایران(IRSA)
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🗒به روز رسانی #اطلاعات

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Diagnosis and treatment of left ventricular dysfunction
and heart failure in cancer patients


#ESC Journals, E-Journal of Cardiology Practice, Volume-16
Vol. 16, N° 40 - 27 Feb 2019
Dr. Alexander R. Lyon , FHFA, Dr. Mohsen Habibian, Dr. Ruben Evertz, Dr. Riccardo Asteggiano , Prof. Thomas M. Suter


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Important Interventional Trials From #ESC #Congress 2019: The THEMIS-PCI

🔸The THEMIS-PCI (Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention) report in Lancet1 found that the primary efficacy outcome (a composite of cardiovascular death, myocardial infarction [MI], or stroke) was lower in patients randomized to ticagrelor than to placebo (404 [7.3%] of 5,558 vs. 480 [8.6%] of 5,596; hazard ratio [HR] 0.85; 95% confidence interval [CI], 0.74-0.97; p = 0.013) in the subgroup of patients with a history of PCI.2 However, THEMIS-PCI has major statistical flaws that limit its generalizability:

1.This was a subgroup analysis. The lay press understands that subdividing a main trial into subgroups is limiting because it introduces spurious results.

2.The p-value describing the interaction between PCI and non-PCI patients for the primary outcome was not significant (p = 0.16). ...

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